منابع مشابه
The congenital and limb-girdle muscular dystrophies: sharpening the focus, blurring the boundaries.
During the past decade, outstanding progress in the areas of congenital and limb-girdle muscular dystrophies has led to staggering clinical and genetic complexity. With the identification of an increasing number of genetic defects, individual entities have come into sharper focus and new pathogenic mechanisms for muscular dystrophies, like defects of posttranslational O-linked glycosylation, ha...
متن کاملNoise drives sharpening of gene expression boundaries in the zebrafish hindbrain
Morphogens provide positional information for spatial patterns of gene expression during development. However, stochastic effects such as local fluctuations in morphogen concentration and noise in signal transduction make it difficult for cells to respond to their positions accurately enough to generate sharp boundaries between gene expression domains. During development of rhombomeres in the z...
متن کاملSharpening the species boundaries in the Cladonia mediterranea complex (Cladoniaceae, Ascomycota)
The complex Cladonia mediterranea belongs to the section Impexae and is formed by C. azorica, C. macaronesica and C.mediterranea. These species are basically distributed in the Mediterranean and Macaronesian Regions. In the present work the limits between the species of this complex are re-examined. To this end, the morphological characters were studied along with the secondary metabolites and ...
متن کاملDevelopment of Efficient Interface Sharpening Procedure for Viscous Incompressible Flows
The paper describes the development of the efficient interface sharpening procedure for viscous incompressible flows governed by the Navier–Stokes equations. The moving interface has been captured by a pseudo-concentration method. The solution domain has been discretised by the space-time finite elements, while numerical schemes have been stabilised by the Galerkin least squares method. The dam...
متن کاملPortfolio Sharpening
We explore the effective gain or loss in alpha from the point of view of the investor due to the volatility of a fund and its correlations to other asset classes. Fund managers and investors can be guided by this to increase the utility that is ultimately delivered to the investor. In this analysis of investor utility the Sharpe ratio is shown to be misleading and the tracking error has no role...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.323.5915.688a